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For topical dermatology compounds—where a 4% hydroquinone cream that tests at 2.8% delivers a meaningfully different clinical effect—this variability has real patient-care implications
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Age, sex, nutritional status, adiposity, dietary preferences, habits such as smoking, use of concurrent medications, physiologic states such as pregnancy, pathologic states such as liver disease, and others can affect one or more of the 3 processes listed above, thereby influencing the half-life of psychotropic and other drugs